Cancer Science & Therapy

Veronica Estrella

Publications

• Research Article
  Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model
  Author(s): Arig Ibrahim-Hashim, Jonathan W. Wojtkowiak, Maria de Lourdes Coelho Ribeiro, Veronica Estrella, Kate M. Bailey, Heather H. Cornnell, Robert A. Gatenby and Robert J GilliesArig Ibrahim-Hashim, Jonathan W. Wojtkowiak, Maria de Lourdes Coelho Ribeiro, Veronica Estrella, Kate M. Bailey, Heather H. Cornnell, Robert A. Gatenby and Robert J Gillies
  
  Background: Malignant tumor cells typically metabolize glucose anaerobically to lactic acid even under normal oxygen tension, a phenomenon called aerobic glycolysis or the Warburg effect. This results in increased acid production and the acidification of the extracellular microenvironment in solid tumors. H + ions tend to flow along concentration gradients into peritumoral normal tissue causing extracellular matrix degradation and increased tumor cell motility thus promoting invasion and metastasis. We have shown that reducing this acidity with sodium bicarbonate buffer decreases the metastatic fitness of circulating tumor cells in prostate cancer and other cancer models. Mathematical models of the tumor-host dynamics predicted that buffers with a pka around 7 will be more effective in reducing intra- and peri-tumoral acidosis and, thus, and possibly more effective in.. Read More»
  DOI: 10.4172/1948-5956.S1-004

  Abstract PDF