Molecular Biology: Open Access

Vijay Hegde

Publications

• Research Article
  Age Dependent Accumulation of Spontaneous DNA Damage in Liver of Transgenic Mice over Expressing Ribosomal Protein S3
  Author(s): Vijay Hegde, Sridevi Yadavilli and Walter A DeutschVijay Hegde, Sridevi Yadavilli and Walter A Deutsch
  
  Oxidative stress has been associated with the aging process and increased cancer incidence mainly due to accumulation of free radical dependent cellular damage. Reactive oxygen species (ROS) induced formation of 7,8-dihydro-8-oxoguanine (8-oxodG) has the potential to mispair with Adenine during DNA replication in key genes involved in the development of cancer. Human ribosomal protein S3 (RPS3) participates in a variety of reactions beyond its role in protein synthesis, such as processing of oxidative DNA damage. We have shown ex vivo that oxidative stress causes RPS3 to translocate to the nucleus, bind to sites of 8-oxodG with an extraordinarily high binding affinity and interferes with 8-oxodG repair in vitro. Furthermore, our in vivo studies using RPS3 over expressing transgenic mice showed translocation of RPS3 to the nucleus in mouse embryonic fibroblasts (MEFs) and co-localizati.. Read More»
  DOI: 10.4172/2168-9547.1000164

  Abstract PDF