Medicinal Chemistry

Vijaya Kumari Dalavai

Publications

• Research Article
  Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives
  Author(s): Bala Guraiah Mothukuri, Triloknadh Settypalli, Nagaraju Begari, Vijaya Kumari Dalavai and Venkata Rao ChunduriBala Guraiah Mothukuri, Triloknadh Settypalli, Nagaraju Begari, Vijaya Kumari Dalavai and Venkata Rao Chunduri
  
  With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-benzo[d]imidazole derivatives were synthesized using condensation reaction of 3-(6-chloro-1H-benzo[d] imidazol-2-yl)propane hydrazide and benzoic acids as key step in presence of POCl3. All newly synthesized target compounds (4a-4n) were characterized by 1H NMR, Mass and IR spectral studies and were screened for their antibacterial activity with two bacterial pathogens (Gram positive: Bacillus subtilis, Gram negative: Escherichia coli) which confirmed that compounds 4a, 4b, 4d, 4g, 4h and 4n have potent activity agains.. Read More»
  

  Abstract PDF