Journal of Computer Science & Systems Biology

Vikram Dhillon

Publications

• Research Article
  Single-Cell Genome Sequencing for Viral-Host Interactions
  Author(s): Vikram Dhillon and Xiaoman LiVikram Dhillon and Xiaoman Li
  
  Viruses are the most abundant biological entities and infectious agents present in almost every ecosystem on the planet. Yet our understanding of how viral-mediated gene transfer and metabolic reprogramming influence the evolutionary history of their hosts and microbial communities remains poor at best. At the same time, identifying and modeling the community dynamics of viruses from the environment through conventional plaque assays is complicated because less than one percent of microbial hosts have been cultivated in vitro. Computational methods in metagenomics and phage isolation techniques have limitations in identifying the uncultured hosts of most viruses. Moreover, the model system-based measurements derived from such techniques rarely reflect the network properties of natural microbial communities. To address these problems, development of high-throughput, massively parallel .. Read More»
  DOI: 10.4172/jcsb.1000183

  Abstract PDF