Medicinal Chemistry

Vikram Pratap Singh Rathod

Publications

• Research Article
  Synthesis, Anticancer and Molecular Docking Studies of 2-(4-chlorophenyl)-5-aryl-1,3,4-Oxadiazole Analogues
  Author(s): Mohamed Jawed Ahsan, Vikram Pratap Singh Rathod, Monika Singh, Ramdayal Sharma, Surender Singh Jadav, Sabina Yasmin, Salahuddin and Pradeep KumarMohamed Jawed Ahsan, Vikram Pratap Singh Rathod, Monika Singh, Ramdayal Sharma, Surender Singh Jadav, Sabina Yasmin, Salahuddin and Pradeep Kumar
  
  Among a series of ten, 2-(4-chlorophrnyl)-5-aryl-1,3,4-oxadiazole analogs, 4c showed maximum activity on various cancer cell lines, with average growth percent of 95.37%. The molecular docking studies for the compounds 4a & 4c showed that the residue Cys797 is present near to the para substitution of phenyl group while the five member oxadiazole ring of ligandswas lying near to Leu792 and Met 793 of EGFR tyrosine kinase active .. Read More»
  DOI: 10.4172/2161-0444.1000154

  Abstract PDF