Journal of Bioanalysis & Biomedicine

Vincent van Ginneken

Publications

• Research Article
  Type 3 Diabetes Reflects Disordered Lipid Metabolism in the Human Brain Related to Higher Degree of Unsaturated Fatty Acids Composition and is not Related to Body Mass Index
  Author(s): Vincent van Ginneken, Evert de Vries, Verheij E and Jan van der GreefVincent van Ginneken, Evert de Vries, Verheij E and Jan van der Greef
  
  In this study we investigated lipid profiles of brain of post mortem type 2 diabetes patients T2DM elderly patients in comparison to a Control group (Co) of the “Netherlands Brain Bank” using LCMS techniques. Here we report that brains of these T2DM patients contain more double bonds and consequently are more rigid. In a small cohort (≈200 patients) we prove that these brain diseases are not interrelated with BMI so obesity is not a major cause. The predicted wave of brain diseases of mild-Alzheimer (m-AD), dementia and depression of the “baby boom generation” might be evolved due to the “fatty” and more “rigid” brain structure due to the quality of fats eaten during earlier lifespan. Our major conclusion is that diabetes and its treatment among T2DM patients are more associated with structural disturbances (lipid composition) in t.. Read More»
  DOI: 10.4172/1948-593X.1000171

  Abstract PDF