Cancer Science & Therapy

Vinod Manglik

Publications

• Research Article
  The Effects of Synthesized Rhenium Acetylsalicylate Compounds on Human Astrocytoma Cell Lines
  Author(s): Hirendra N. Banerjee, Deidre Vaughan, Ava Boston, Gabriel Thorne, Gloria Payne, Josiah Sampson, Vinod Manglik, Pola Olczak, Brent V. Powell, Angela Winstead, Roosevelt Shaw and Santosh K MandalHirendra N. Banerjee, Deidre Vaughan, Ava Boston, Gabriel Thorne, Gloria Payne, Josiah Sampson, Vinod Manglik, Pola Olczak, Brent V. Powell, Angela Winstead, Roosevelt Shaw and Santosh K Mandal
  
  Purpose: Because of the scarcity of suitable brain cancer drugs, researchers are frantically trying to discover novel and highly potent drugs free of side effects and drug-resistance. Rhenium compounds are known to be nontoxic and exhibit no drug resistance. For that reason, we have developed a series of novel rhenium acetylsalicylato (RAC or ASP) complexes to test their cytotoxicity on brain cancer cells. Also we have attempted to explore the DNA binding properties of these compounds because many drugs either directly or indirectly bind to DNA. Methods: We have treated the RAC series compounds on human astrocytoma brain cancer cell lines and rat normal brain astrocyte cells and determined the efficacy of these complexes through in vitro cytotoxicity assay. We carried out the DNA-binding study through UV titrations of a RAC compound with DNA. Also we attempted to determine the planari.. Read More»
  DOI: 10.4172/1948-5956.1000512

  Abstract PDF