Metabolomics:Open Access

Virendra Gomase

Publications

• Research Article
  Immunoproteomics Approach for Development of Synthetic Peptide Vaccine from Thioredoxin Glutathione Reductase
  Author(s): Somnath Waghmare, Virendra Gomase, Jaywant Dhole and Ramrao ChavanSomnath Waghmare, Virendra Gomase, Jaywant Dhole and Ramrao Chavan
  
  Schistosomiasis is the second most widespread human parasitic disease. It is principally treated with one drug, praziquantel, which is administered to 100 million people each year; less sensitive strains of schistosomes are emerging. One of the most appealing drug targets against schistosomiasis is thioredoxin glutathione reductase (TGR). This natural chimeric enzyme is a peculiar fusion of a glutaredoxin domain with a thioredoxin selenocysteine (U)-containing reductase domain. Selenocysteine is located on a flexible C-terminal arm that is usually disordered in the available structures of the protein and is essential for the full catalytic activity of TGR. MHC molecules are cell surface pro.. Read More»
  DOI: 10.4172/2153-0769.1000111

  Abstract PDF