Journal of AIDS & Clinical Research

Vonthanak Saphonn

Publications

• Research Article
  HIV-1 Protease Inhibitors Resistance Profiles in Patients with Virological Failure on LPV/r-based 2nd Line Regimen in Cambodia
  Author(s): Eric Nerrienet, Janin Nouhin, Sopheak Ngin, Olivier Segeral, Sreymom Ken, Kerya Phon, Chanroeurn Hak, Vara Ouk, Vonthanak Saphonn, Laurent Ferradini and Jean-Francois DelfraissyEric Nerrienet, Janin Nouhin, Sopheak Ngin, Olivier Segeral, Sreymom Ken, Kerya Phon, Chanroeurn Hak, Vara Ouk, Vonthanak Saphonn, Laurent Ferradini and Jean-Francois Delfraissy
  
  Objective: To describe the ARV resistance profiles of patients experiencing virological failure after at least 6 months on LPV/r-based 2nd line regimen in Cambodia. Design: Retrospective analysis of resistance testing of 89 patients with detectable viral load under LPV/r-based 2nd line regimen. Methods: Bulk sequencing of HIV-1 protease, reverse transcriptase and integrase PCR products. Results: Protease gene amplification was successful for 71/89 patients (80%). All were infected by CRF01_AE viruses. Among them, 42 did not present any resistance to PIs. A high level of resistance to PIs was observed for the 29 remaining patients. Twenty-six were resistant to LPV/r (8 possibly resistant). Twenty-eight, 21 and 20 were also found resistant to IDV, ATV/r and FPV/r, respectively. Twenty-six were resistant to NFV (11 possibly) and 22 to SQV/r (9 possibly). Finally, 22/29 (7.. Read More»
  DOI: 10.4172/2155-6113.S5-003

  Abstract PDF