Journal of AIDS & Clinical Research

Vubil A

Publications

• Research Article
  Genetic Diversity and Transmitted Drug Resistance of HIV-1 Subtypes in Blood Donors Candidates in Northern Mozambique
  Author(s): Vubil A, Jani VI, Mabunda N, Ismael N, Ramalho D, Morgado MG and Couto-Fernandez JCVubil A, Jani VI, Mabunda N, Ismael N, Ramalho D, Morgado MG and Couto-Fernandez JC
  
  In order to evaluate the genetic diversity of HIV-1 subtypes and transmitted drug resistance (TDR) mutations in northern Mozambique, we analyzed 120 plasma specimens obtained from drug naive blood donors candidates, who tested positive during routine HIV screening in three blood banks in that region. The genotyping for HIV-1 resistance was performed using Trugene Genotyping SystemTM. HIV-1 genetic subtypes were defined based on entire PR and partial RT gene regions, using REGA HIV-1 Subtyping Tool version 3.0 algorithm and confirmed by phylogenetic inference, using NJ algorithm. The majority of genotyped samples were classified as HIV-1 subtype C (80.0%), followed by subtype A1 (10.5%), subtype D (3.2%) and subtype G (2.1%). The inter-subtype recombinant forms (A1/C, A1/D and C/D) were identified in four participants (4.2%). TDR mutations associated with nucleoside an.. Read More»
  DOI: 10.4172/2155-6113.1000623

  Abstract PDF