Journal of Cytology & Histology

Wael M Elsaed

Publications

• Research Article
  Agmatine Ameliorates Nicotine Induced Lung Injury in Rats through Decrease TGF-Ã?Æ?Ã?Ÿ1 and Bax Immunoexpression and by Anti-oxidative Sress Pathway: Histological, Immunohistochemical and Biochemical Study
  Author(s): Ghalia M Attia, Manar Ahmed Nader, Rasha A Elmansy and Wael M ElsaedGhalia M Attia, Manar Ahmed Nader, Rasha A Elmansy and Wael M Elsaed
  
  Introduction: Nicotine (NIC), the chief alkaloid in tobacco, believed to be an active agent responsible for lungassociated diseases. This protocol targeted to analyze the ameliorating effect of agmatine (AG) on NIC induced lung damage. Mateiral and methods: Forty-five adult male rats were divided into: Control group received intraperitoneal (IP) injection of distilled water, 2) NIC group recieved NIC (10 mg/kg/day) IP and 3) (NIC+AG) group treated by AG (10 mg/kg/day) orally+NIC (10 mg/kg/day) by IP injection for 9 weeks. Total serum protein, triglycerides (TGs), total cholesterol (TC), high density lipoprotein (HDL), Low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH) and vascular cell adhesion molecule 1 (VCAM- 1) were estimated. Lung specimens were prepared and stained with H&E, Masson trichrome and immunehis.. Read More»
  DOI: 10.4172/2157-7099.1000458

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