Journal of Computer Science & Systems Biology

Walter J Lukiw

Publications

• Research Article
  An Exploratory Analysis of Conservation of Co-Expressed Genes across Alzheimer's disease Progression
  Author(s): Pradeep Chowriappa, Prerna Dua and Walter J LukiwPradeep Chowriappa, Prerna Dua and Walter J Lukiw
  
  Alzheimer’s disease (AD) is a complex disease where the analysis of gene expression patterns relies on computational techniques to understand the cause and progression of the disease. Evidence postulates that the complexity of AD stems from the overlap of early-stage markers with normal aging. Furthermore, there is increasing evidence suggesting that gene co-regulation in AD plays a vital role in the progression of the disease. The aim of this work is to identify and track co-regulated genes from incipient to severe cases of AD i.e. samples that exhibited progression of AD. We hypothesize that co-expressed genes associated with two markers of AD (the cognitive marker-mini mental state examination (MMSE) and the pathological marker Neurofibrillary Tangles (NFT)), are conserved across AD progression. For our analysis we used the Blalock dataset and the.. Read More»
  DOI: 10.4172/jcsb.1000119

  Abstract PDF