Molecular Biomarkers & Diagnosis

Wayne L

Publications

• Research Article
  Microcytosis and Alpha and Beta Thalassaemia in Prospective Blood Donors of East Indian Descent in Trinidad and Tobago
  Author(s): Sehlule V, Hasina M, Wayne L, George L, Angel A J V, Marie-Dominique HD, Marc R and Christian SMSehlule V, Hasina M, Wayne L, George L, Angel A J V, Marie-Dominique HD, Marc R and Christian SM
  
  Background: People of East Indian descent account for 40% of the Trinidad and Tobago (TT) population. Most came from Uttar-Pradesh and West Bengal in India where thalassaemia is prevalent. The thalassaemia carrier frequency and exact mutations are unknown in TT. Diagnostic DNA analysis is not routinely available. Objective: To estimate the carrier frequency of thalassaemia among prospective blood donors. Method: Blood samples were obtained from 125 prospective blood donors of East-Indian origin. CBC was done to screen for microcytosis(MCV≤83 fL). Microcytic samples had ferritin, transferrin saturation, haemoglobin electrophoresis, haemoglobin A2/F quantification and DNA analysis performed performed for thalassaemia. Results: 72.4% subjects were male and 26.4% female. Microcytosis was f.. Read More»
  DOI: 10.4172/2155-9929.1000227

  Abstract PDF