Journal of Cytology & Histology

Weder W

Publications

• Research Article
  A Comprehensive Analysis of Markers for Neuroendocrine Tumors of the Lungs Demonstrates Estrogen Receptor Beta to be a Prognostic Markers in SCLC Male Patients
  Author(s): Curioni-Fontecedro Alessandra, Soldini D, Seifert B, Eichmueller T, Korol D, Moch H, Weder W and Stahel RACurioni-Fontecedro Alessandra, Soldini D, Seifert B, Eichmueller T, Korol D, Moch H, Weder W and Stahel RA
  
  Knowledge about the biology and prognostic markers of neuroendocrine tumours (NET) of the lungs is scarce. As sex steroids contribute to cell proliferation in various human tissues, we aimed at characterising the expression of steroid receptors in a broad cohort of probes from NET of the lungs and evaluated their possible prognostic impact. A total of 192 tumour specimens of NET of the lungs were collected, with 58 surgical specimens of typical carcinoids, 42 of atypical carcinoids, 32 of large cell neuroendocrine carcinomas and 60 of small cell lung cancer (SCLC). Analysis by immunohistochemistry for the following antigens was performed: estrogen receptor β (ERβ), ERα, PR (progesterone receptor), AR (androgen receptor), Thyroid transcription factor 1 (TTF1), synaptophysin and for chromograninA. ERβ was found to be expressed in more than 60% of tumor probes. Survi.. Read More»
  DOI: 10.4172/2157-7099.1000268

  Abstract PDF