Molecular Biology: Open Access

Weikuan Gu

Publications

• Research Article
  Sex Difference in the Expression and Gene Network of Epidermal Growth Factor Receptor in Pituitary Gland in Mice
  Author(s): Weikuan Gu, Yuhan Chen, Chuanming Liu, Qingyi Liu, Fengxia Liu, Helin Feng, Yan Jiao, Hassan Almoazen and Jiaqian ZhuWeikuan Gu, Yuhan Chen, Chuanming Liu, Qingyi Liu, Fengxia Liu, Helin Feng, Yan Jiao, Hassan Almoazen and Jiaqian Zhu
  
  Background: Epidermal growth factor receptor (EGFR) involves in diverse cellular functions and plays an important role in the pathogenesis of many malignancies in the human population. The pituitary gland is a target of epidermal growth factor (EGF) and it is well known that EGFR plays a role in pituitary tumor as well as other tumors formation and progression. Methods: In this study, we have screened expression profiles for the whole genome of pituitary genes of both sexes from multiple mouse recombinant inbred strains. In addition, using Network Graph, we have constructed the gene network in combination with the correlation matrix. To determine the chromosomal locations that regulate the expression of Egfr in females and males, the transcriptome mapping was conducted using Gene Network mapping tool. Furthermore, we conducted bioinformatics a.. Read More»
  DOI: 10.4172/2168-9547.1000179

  Abstract PDF