Journal of AIDS & Clinical Research

Wen Guo

Publications

• Research Article
  Lopinavir/Ritonavir Impairs Physical Strength in Association with Reduced Igf1 Expression in Skeletal Muscle of Older Mice
  Author(s): Siu Wong, Shalender Bhasin, Carlo Serra, Yanan Yu, Lynn Deng and Wen GuoSiu Wong, Shalender Bhasin, Carlo Serra, Yanan Yu, Lynn Deng and Wen Guo
  
  Background: Late-middle age HIV patients are prone to fatigue despite effective viral control by antiretroviral therapies. Rodent models to recapitulate this phenotype are still not available. Hypothesis: Drug treatment may compromise muscle strength and physical performance more in older individuals with pre-existing metabolic disorders than normal young ones. Methods: Kaletra was given to overweight male mice at late-middle age and normal young adults; both on a rodent diet containing 30% fat calorie. Body composition and grip strength were measured at baseline and after drug treatment. Rota-rod running, insulin and glucose tolerance were measured at the end of the experiment. Drug effect on metabolic activity and spontaneous movements were assessed using the metabolic cage system. Representative muscle and fat tissue were analyzed for protein and mRNA expression. Selected f.. Read More»
  DOI: 10.4172/2155-6113.1000216

  Abstract PDF