Transplantation Technologies & Research

Wen Ji-qiu

Publications

• Research Article
  Clinical and Pathological Study of Polyomavirus-Associated Nephropathy after Renal Transplantation
  Author(s): JI Shu-ming, Xie Ke-nan, Chen Jin-song, Wen Ji-qiu, Cheng Dong-rui, LI xu, NI Xue-feng and Liu Zhi-hongJI Shu-ming, Xie Ke-nan, Chen Jin-song, Wen Ji-qiu, Cheng Dong-rui, LI xu, NI Xue-feng and Liu Zhi-hong
  
  Polyomavirus infection has emerged as an important cause of polyomavirus-associated nephropathy (PVAN) leading to allograft dysfunction and loss. The aim of this study is to investigate pathological features and clinical characteristics of PVAN. We prospectively investigated 351 renal allografts performed in Jinling Hospital. PVAN was diagnosed by light microscopic examination and a positive immunohistochemistry staining of anti-SV40 large T antibody in a biopsy specimen. 31 patients were diagnosed with PVAN (8.8%). The patients with PVAN typically presented as allograft dysfunction with an asymptomatic rise in serum creatinine about 3 to 39 months posttransplant. Urinary decoy cells were positive in 4 patients (12.9%). The histologic changes of PVAN are not pathognomonic and can be mistaken for allograft rejection, i.e. tubulointerstitial nephritis with varying degrees of inflammator.. Read More»
  DOI: 10.4172/2161-0991.1000132

  Abstract PDF