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Journal of Nephrology & Therapeutics

ISSN: 2161-0959

Open Access

Wen-Chih Liu

Cardinal Tien Hospital,
Yonghe Branch, 80 Zhongxing St., Yonghe Dist., New Taipei City 234
People’s Republic of China

Publications
  • Review Article
    Bone Turnover and Vascular Calcification
    Author(s): Pei-Chen Wu, Cai-Mei Zheng, Min-Tser Liao, Chia-Chao Wu, Kuo-Cheng Lu and Wen-Chih LiuPei-Chen Wu, Cai-Mei Zheng, Min-Tser Liao, Chia-Chao Wu, Kuo-Cheng Lu and Wen-Chih Liu

    The impaired bone mineral metabolism followed byVascular Calcification (VC) will be presentat the beginning stage of Chronic Kidney Disease (CKD). VC can be considered as two major types, which are intimal calcification, associated with atherosclerosis, and medial calcification that involves damaged vascular smooth muscle cells (VSMCs), which leads to increase vascular stiffness and decrease vascular elasticity. Many factors control the mechanisms, and they are imbalances in serum calcium and phosphate, systemic inflammation, hyperparathyroidism, increased matrix degradation, VSMC apoptosis, decreased matrix glutamate protein, etc. These will make VSMCs Trans differentiation to phenotypic osteoblastic cells. In addition, patients with CKD usually have bone turnover problems. For a high turnover status, secondary hyperparathyroidism increases calcium and phosphate release from the bone.. Read More»
    DOI: 10.4172/2161-0959.1000171

    Abstract PDF

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Google Scholar citation report
Citations: 784

Journal of Nephrology & Therapeutics received 784 citations as per Google Scholar report

Journal of Nephrology & Therapeutics peer review process verified at publons

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