China
Research Article
Effects of a Long Term Physical Exercise on the mrna Level of BDNF in Mice after Middle Cerebral Artery Occlusion
Author(s): Qian Gao, Gang Wang, Fei Wang, Wenyu Zhang and Hong QingQian Gao, Gang Wang, Fei Wang, Wenyu Zhang and Hong Qing
Backgroud: BDNF plays an important role in maintaining survival and function of neurons. Exercise may be increasing the mRNA and protein level of BDNF in hippocampus and cortex.
Objective: To investigate the impact of a long-term physical training on the mRNA and protein level of BDNF after Middle Cerebral Artery Occlusion (MCAO) in mice.
Design, Time and Seting: A randomized, controlled, animal experiment was performed at the department of rehabilitation medicine, Chinese PLA general hospital
Materials: Twenty-six male C57 BL/6J mice (20–30g, 2-3 months old) were provided by Experimental Animal Center of Institute of Medicine, Chinese PLA general hospital.
Methods: Twenty-six male C57 BL/6J mice underwent MCAO (described by Bederson JB et al) and then were divided in.. Read More»
DOI:
10.4172/2376-0281.1000170
International Journal of Neurorehabilitation received 1078 citations as per Google Scholar report