Journal of AIDS & Clinical Research

William Kudzi

Publications

• Research Article
  Risk Factors of Nevirapine Hypersensitivity Reaction among Human Immunodeficiency Virus-1 Infected Treatment Naïve Patients at Korle-Bu Teaching Hospital
  Author(s): William Kudzi, Elvis Twumasi Aboagye, Bartholomew Dzudzor, Edmund Tetteh Nartey and Daniel Gyingiri AchelWilliam Kudzi, Elvis Twumasi Aboagye, Bartholomew Dzudzor, Edmund Tetteh Nartey and Daniel Gyingiri Achel
  
  Objective: Ghana like most African countries, still carry the communicable disease burden. The introduction of antiretroviral drugs in Ghana has improved survival rates amongst HIV patients. According to the National Guidelines for antiretroviral treatment in Ghana, administration of nevirapine, a frontline antiretroviral drug leads to hypersensitivity reactions in some patients. This study examines the clinical risk factors and specific genotypic alleles associated with nevirapine hypersensitivity reactions. Methods: Seventy (70) antiretroviral naïve HIV patients, initiating nevirapine-based HAART therapy were enrolled in this cohort study and monitored clinically over a period of 24 weeks from July 2013 through to June 2014. Blood samples were evaluated for aminotransferase activity and DNA genotyped for specific ABCB1 and CYP2B6 markers. Results: Eleven (15.7%) patients were.. Read More»
  DOI: 10.4172/2155-6113.1000654

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