Neurological Disorders

Winnie Thomas

Publications

• Research Article
  Evaluation of C677T Polymorphism of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in various Neurological Disorders
  Author(s): Sireesha Divyakolu, Yadavalli Tejaswini, Winnie Thomas, Sravya Thumoju, Vemula Ramana Sreekanth, Mohan Vasavi, Vallomkonda Ramesh OmSai, Vallomkonda Nagaratna, Qurratulain Hasan and Yog Raj AhujaSireesha Divyakolu, Yadavalli Tejaswini, Winnie Thomas, Sravya Thumoju, Vemula Ramana Sreekanth, Mohan Vasavi, Vallomkonda Ramesh OmSai, Vallomkonda Nagaratna, Qurratulain Hasan and Yog Raj Ahuja
  
  Abstract Background: Genetic risk factors play an important role in neurological disorders. In this case-control study, we examined the C677T polymorphism (rs1801133) in the Methylenetetrahydrofolate reductase (MTHFR) gene and its association with three neurodegenerative disorders: The late onset pathology, Alzheimer disease and two early onset ones, Autism and Down syndrome. New evidence suggests that autism may be associated with varied behavioural responses to folate therapy and metabolic anomalies, including those in folate metabolism, that contribute to hypomethylation of DNA. We hypothesis that, MTHFR C677T mutation may be the underlying common risk factor in various neurological disorders leading to impaired one carbon metabolism resulting in similar and severe neuropsychological symptoms. Hence our objective was to evaluate MTHFR C677T polymorphism in different Neuro.. Read More»
  DOI: 10.4172/2329-6895.1000142

  Abstract PDF