Environmental & Analytical Toxicology

WS Timberlake

Publications

• Review Article
  Caenorhabditis elegans: An Emerging Model System for Pesticide Neurotoxicity
  Author(s): KA McVey, JA Mink, IB Snapp, WS Timberlake, CE Todt, R Negga and VA FitsanakisKA McVey, JA Mink, IB Snapp, WS Timberlake, CE Todt, R Negga and VA Fitsanakis
  
  An ideal model organism should generally have three essential characteristics: successful sexual crosses should be easy to perform; a fully sequenced genome should be available; and it should be easy to induce reliable and reproducible DNA mutations. The nematode Caenorhabditis elegans (C. elegans), introduced to the broad scientific community by Brenner in 1974, fulfills each of these three essential guidelines. Although initially used extensively by the developmental biology community, its recent adoption by the biomedical and environmental toxicology scientists has strengthened experimental design power in these fields. Relative to traditional model organisms, e.g. rat, mouse, dog (mammals) and Arabidopsis (plants), the invertebrate species C. elegans has begun to be recognized as invaluable. For example, it requires a relatively small budget project compared to other possible orga.. Read More»
  DOI: 10.4172/2161-0525.S4-003

  Abstract PDF