Metabolomics:Open Access

Xi Yang

Publications

• Research Article
  Urinary Micrornas as Noninvasive Biomarkers for Acetaminophen- Induced Liver Injury
  Author(s): Xi Yang, Zhiguang Li, Zhenqiang Su, Kelly Davis, Tao Chen, Donna L Mendrick and William SalminenXi Yang, Zhiguang Li, Zhenqiang Su, Kelly Davis, Tao Chen, Donna L Mendrick and William Salminen
  
  Several recent studies measured elevated levels of circulating plasma microRNAs (miRNAs) after toxicant-induced liver injury, most likely due to leakage from damaged hepatocytes. miRNAs have also been detected in urine with some of them being derived from organs outside of the urinary system, opening up their potential use as noninvasive biomarkers of disease or injury. Despite this potential, changes in urine miRNA profiles have not been investigated as biomarkers for drug-induced liver injury. In this study, urine miRNA profiles were assessed from rats treated with a single oral dose of acetaminophen (APAP: 100 or 1250 mg/kg). The low dose did not cause any clinical pathology or histopathological changes indicative of liver injury. In contrast, the high dose increased clinical pathology and histopathological indices of liver injury at 24 hours; however, there was a high inter-animal.. Read More»
  DOI: 10.4172/2153-0769.1000101

  Abstract PDF