Journal of Bioanalysis & Biomedicine

Xianbiao Xie

Publications

• Research Article
  Gas6/Axl Inhibits Osteosarcoma Apoptosis through Regulation of Apoptosis-Related Protein Bcl-2
  Author(s): Nian Jiang, Yingrong Lai, Rui Tian, Xianbiao Xie, Ju Han, Ni Liu, Canqiao Luo and Tingsheng PengNian Jiang, Yingrong Lai, Rui Tian, Xianbiao Xie, Ju Han, Ni Liu, Canqiao Luo and Tingsheng Peng
  
  Background: Dysregulation of the receptor tyrosine kinase Axl and its ligand Gas6 has been shown to promote the progression of osteosarcoma and correlates with poor prognosis. This study aimed to identify the role of Gas6/ Axl for anti-apoptosis as induced by cisplatin (DDP) and methotrexate (MTX) chemotherapy and to analyze the relationship between P-Axl and apoptosis-related proteins in osteosarcoma. Method: Cultured osteosarcoma cell lines MG63, 143B and U2OS were used for apoptosis assays, Axl siRNA transfection, cytotoxicity assays, cell cycle analysis, and other assessment methods. A total of 41 cases of osteosarcoma patients were included for immunohistochemistry staining and clinicopathological relative analysis. TUNEL assay was performed in ten pair’s cases for apoptosis detection and relative analysis of P-Axl. .. Read More»
  DOI: 10.4172/1948-593X.1000145

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