Journal of Clinical & Medical Genomics

Xiang-Pei Li

Publications

• Research Article
  Association of P2X7R Functional Expression and Gene Polymorphisms with Systemic Lupus Erythematosus
  Author(s): Jin-Hui Tao, Jiang-Ping Tang, Mei-Yun Wang, Hai-Feng Pan, Rui-Xue Leng, Yan-Feng Zou, Dong-Qing Ye and Xiang-Pei LiJin-Hui Tao, Jiang-Ping Tang, Mei-Yun Wang, Hai-Feng Pan, Rui-Xue Leng, Yan-Feng Zou, Dong-Qing Ye and Xiang-Pei Li
  
  Objective: To investigate P2X purinoceptor 7 (P2X7R) expression changes on peripheral blood mononuclear cell (PBMC) surfaces of systemic lupus erythematosus (SLE) patients as well as their association with serum cytokine levels and patients’ clinical features. In addition, the effects of different P2X7R single nucleotide polymorphisms (SNPs) on P2X7R expression and cytokine production were investigated. Method: Twenty-nine new-onset SLE patients and twenty-eight healthy controls were enrolled, while P2X7R expression levels of lymphocytes, CD4+ cells and CD19+ cells were analyzed by flow cytometry. Serum IL-1β, IL-6 and TNF-α levels were analyzed by ELISA and three P2X7R SNPs (1068G>A, 1096C>G and 1513A>C) were PCR genotyped in 14 SLE patients and 14 healthy controls. Results: P2X7R surface.. Read More»
  DOI: 10.4172/2472-128X.1000131

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