Journal of Nephrology & Therapeutics

Xiaohua Guo

Publications

• Research Article
  Beneficial Effect of Rhein on the Treatment of Diabetic Nephropathy in Nonobese Diabetic (NOD) Mice
  Author(s): Zhonghui Jia, Xiaohua Guo, Jianping Wang and Zhihong LiuZhonghui Jia, Xiaohua Guo, Jianping Wang and Zhihong Liu
  
  Objective: Rhein has been discovered early to have the function of inhibiting both electron transfer and ADP- driven H + uptake in mitochondria. It has been also found that rhein can inhibit the up regulation of GLUT1 (glucose transporting protein-1) function and the activity of hexosamine biosynthetic pathway in mesangial cells in vitro. Futhermore, we have showed the renal protective effect of rhein on STZ-induced diabetic rats. So we try to explore the therapeutic effects of rhein on diabetic nephropathy (DN) in another diabetic model of NOD mice. Methods: In our study, NOD mice of eight weeks of age were injected intraperitoneally four times with STZ (50 mg/kg) at 7-day interval. Mice with glycosuria and plasma glucose level above 14.0 mmol/L were verified for diabetes. Dia.. Read More»
  DOI: 10.4172/2161-0959.1000112

  Abstract PDF