Journal of Spine

Xin Lin

Publications

• Research Article
  Association of Bone Morphogenic Protein Receptor IA (BMPIA) Gene Polymorphism with Ossification of Posterior Longitudinal Ligament (OPLL) of the Cervical Spine in a Chinese Han Population
  Author(s): Weitao Jin, Hui Yang, Chunli Zhao, Xin Lin and Hao WangWeitao Jin, Hui Yang, Chunli Zhao, Xin Lin and Hao Wang
  
  Study design: A case-control study using radiograph findings and the PCR assay with regard to the susceptibility and the severity of ossification of posterior longitudinal ligament of the spine (OPLL). Objective: To analyze whether the single nucleotide polymorphisms in the Bone Morphogenetic Protein Receptor IA (BMPIA) gene predisposed to increased the frequency and severity of OPLL. Methods: Analysis of 292 OPLL patients and 586 non-OPLL controls was performed. Radiographs of the cervical spine were analyzed to determine whether OPLL was present and to what degree. Genomic DNA was extracted from all participants. Polymorphisms of the BMPRIA gene were analyzed using the PCR assay. The association of the polymorphisms with the development and extent of OPLL were statistically evaluated. Results:.. Read More»
  DOI: 10.4172/2165-7939.1000131

  Abstract PDF