Journal of Bioengineering & Biomedical Science

Xinghua Pan

Publications

• Research Article
  Cellulose Monolith with Tunable Functionality for Immobilization of Influenza Virus
  Author(s): Xinghua Pan, Sudheer Jinka, Vinit Kumar Singh, Seshadri Ramkumar and M Nazmul KarimXinghua Pan, Sudheer Jinka, Vinit Kumar Singh, Seshadri Ramkumar and M Nazmul Karim
  
  Advancements in influenza virus or virus like particle separation technology can greatly accelerate vaccine production. Due to frequent mutation of the influenza virus, rapid and effective separation of influenza virus directly from host cells still remains a challenge. In this paper, we developed a new cellulose fiber monolith-based chromatography with tunable anion exchange and pseudo-affinity modifications for the separation of cell cultureproduced influenza virus. A novel strategy is proposed for preparing cellulose fiber monolith, which enhances the mechanical property of the monolith. Controllable pore size and porosity were achieved by dispersing and removing a porogen into cellulose-dissolving solution. The structure of cellulose monolith was characterized by Scanning Electron Microscope and the porosity study, which confirmed the controllable average pore size of 10 micron an.. Read More»
  DOI: 10.4172/2155-9538.1000246

  Abstract PDF