Journal of Hypertension: Open Access

Xinghui Li

Publications

• Research Article
  Angiotensinogen M235T, β2 Adrenergic Receptor Arg16Gly and Aldosterone Synthase C-344T Gene Polymorphisms and Essential Hypertension among Han Population Living at High Altitude in China
  Author(s): Xinghui Li, Yan Qiao, Yingdong Li, Hui Cai, Jin He, Yan Huang, Ping Xie, Haizhong Ma and R DevasundaramXinghui Li, Yan Qiao, Yingdong Li, Hui Cai, Jin He, Yan Huang, Ping Xie, Haizhong Ma and R Devasundaram
  
  We explored the association of angiotensinogen (AGT) M235T, β2 adrenergic receptor (β2-AR) Arg16Gly and aldosterone synthase (CYP11B2) C-344T genes polymorphisms with essential hypertension (EH) in Han population living at high altitude in China. A total of 390 hypertensive subjects (males, 207; females, 183) and 424 normal healthy individuals (males, 251; females, 173) were enrolled in this study based on the inclusion and exclusion criteria. The polymorphisms of AGT M235T, β2-AR Arg16Gly, CYP11B2 C-344T genes were analyzed by Snapshot mini sequencing method. The frequencies of CC genotype and C allele of AGT M235T in EH group were higher than in control (p<0.05), gender wise analysis revealed that the genotype and allele patterns between patients and controls were found to be significantly different (p<0.05). However, genotype and allele frequencies of the distr.. Read More»
  

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