Molecular Biomarkers & Diagnosis

Xiomara Escobar

Publications

• Research Article
  Immunoreaction of 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside Correlates with High Histological Grade in some Tumors of Neuroectodermal and Epithelial Lineage
  Author(s): Rancés Blanco, Damián Blanco, Xiomara Escobar, Charles E. Rengifo, Mercedes Cedeño, Rosa Irene Alvarez, Enrique Rengifo and Adriana CarrRancés Blanco, Damián Blanco, Xiomara Escobar, Charles E. Rengifo, Mercedes Cedeño, Rosa Irene Alvarez, Enrique Rengifo and Adriana Carr
  
  The aberrant expression of N-glycolyl GM3 ganglioside (NeuGcGM3) has been reported in a variety of malignant tumors. Nevertheless, the relationship between NeuGcGM3 expression and aggressive biological behavior still remains unclear for the majority of malignancies. In this article the tissue reactivity of the 14F7 monoclonal antibody, a highly specific IgG1 against NeuGcGM3, in breast cancer, urinary bladder tumors and malignant gliomas of adult patients is shown as well as its relation with the histological grade of these malignancies. The expression of NeuGcGM3 was detected in 92/155 (59.3%) of tumors independently of the histopathological classification. However, a preferential expression of NeuGcGM3 was detected in: infiltrating ductal carcinoma (77.1%) vs. infiltrating lobular carcinoma (15.9%) (p=0.024), grade III (94.9%) vs. grade II (77.8%) and grade I (63.8%) transitional ce.. Read More»
  DOI: 10.4172/2155-9929.1000252

  Abstract PDF