Medicinal Chemistry

Xuexia Lu

Publications

• Research Article
  Development and Validation of a Method for Determination of Encapsulation Efficiency of CPT-11/DSPE-mPEG2000 Nanoparticles
  Author(s): Chan Li, Xianlei Li, Shuyi Li, Yuhua Weng, Kaiyuan Wang, Tingbin Zhang, Shizhu Chen, Xuexia Lu, Yonggang Jiang, Jing Xu and Xingjie LiangChan Li, Xianlei Li, Shuyi Li, Yuhua Weng, Kaiyuan Wang, Tingbin Zhang, Shizhu Chen, Xuexia Lu, Yonggang Jiang, Jing Xu and Xingjie Liang
  
  Herein we report development and validation of the method for evaluating the encapsulation efficiency of a micelle-based nanosystem composed of irinotecan hydrochloride (CPT-11) and an amphiphilic molecule DSPEmPEG2000. The results showed that the centrifugation method can be used for separation of free drug, a critical step in measuring encapsulation efficiency, and the EE of three batches of CPT-11/DSPE-mPEG2000 micelles was 90.0% ± 1.0%. The results also indicated that the conditions used in the process have to be optimized to acquire reliable data. .. Read More»
  DOI: 10.4172/2161-0444.1000368

  Abstract PDF