Environmental & Analytical Toxicology

Yan-Ping Lin

Publications

• Research Article
  Comparison of Electron Impact and Electron Capture Negative Ionization for the Quantification of Polybrominated Diphenyl Ethers in Human Plasma
  Author(s): Yan-Ping Lin, Isaac N. Pessah and Birgit PuschnerYan-Ping Lin, Isaac N. Pessah and Birgit Puschner
  
  Polybrominated diphenyl ethers (PBDE) are persistent organic pollutants that are strongly associated with disrupted endocrine and immune functions. Due to the increasing health concerns, it is critical to quantify PBDEs in human specimens. Gas chromatography (GC) - mass spectrometry (MS) with electron impact (EI) and electron capture negative ionization (ECNI) sources were optimized to compare the quantification for ten PBDEs in 0.5 ml of human plasma. Source parameters, including electron energy, emission current, source temperature, focus lens and flow rate of the ECNI source reagent gas (methane), were optimized to achieve the best performances of EI-MS and ECNI-MS. The limits of quantification (LOQ) in human plasma ranged from 20 to 497 fg injected into GC/ECNI-MS compared to 519 to 2966 fg when using GC/EI-MS. Especially for highly brominated congener.. Read More»
  DOI: 10.4172/2161-0525.1000322

  Abstract PDF