Medicinal Chemistry

Yaricruz Pineda

Publications

• Research Article
  Synthesis, Characterization and Antibacterial Activity of a Tridentate Schiff Base Derived from Cephalexin and 1,6-Hexanediamine and its Transition Metal Complexes
  Author(s): Juan Anacona, Yaricruz Pineda, Alina Bravo and Juan CamusJuan Anacona, Yaricruz Pineda, Alina Bravo and Juan Camus
  
  Background: The wide use of the antibiotics resulted in the serious medical problem of drugs resistance and public health concern. Preparation of new synthetic derivatives of antibiotics with novel mechanism of action has become an important task to cope with drug resistanceproblems. Objectives: The goal of the present study is to prepare a family of new metal(II) coordination compounds of Mn, Co, Ni, Cu and Zn with a Schiff base (HL) derived from the condensation of cephalexin antibiotic with 1,6-hexanediamine and to investigate the antibacterial activity of the free cephalexin and the synthesized complexes against gram positive and gram negative strains. Methods: Several physicochemical and spectroscopic methods including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR.. Read More»
  DOI: 10.4172/2161-0444.1000385

  Abstract PDF