Transplantation Technologies & Research

Yasuharu Urano

Publications

• Research Article
  A Histone Deacetylase Inhibitor, FR276457, Altered Characteristics of Infiltrating Cells into Allograft in a Rat Cardiac Transplant Model
  Author(s): Fumitaka Kinugasa, Toshiko Yamada, Takahisa Noto, Yasuharu Urano and Shoji TakakuraFumitaka Kinugasa, Toshiko Yamada, Takahisa Noto, Yasuharu Urano and Shoji Takakura
  
  Background: A recent study indicated that FR276457, a pan-histone deacetylase inhibitor, prevented allograft rejection in an ACI-to-Lewis rat heart transplant model, seemingly without affecting cellular infiltration into the transplanted heart. In this report, we investigated alterations in infiltrating cells in allografts by treatment of FR276457. Materials and Methods: Heterotopic cardiac allografts which were removed from August Copenhagen Irish rats were transplanted into the necks of Lewis rats. FR276457 40 mg/kg or vehicle was subsequently administered orally for 5 consecutive days beginning on the operation day after recovery from anesthesia (Day 0). The allograft recipients were sacrificed under anesthesia on Day 5 after transplantation. At first, we identified infiltrating cells into the allografts by the histopathological analysis. I.. Read More»
  DOI: 10.4172/2161-0991.1000111

  Abstract PDF