Pulmonary & Respiratory Medicine

Yasunori Sohara

Publications

• Research Article
  Morphological Characteristics of a Rat Model of Reexpansion Pulmonary Edema
  Author(s): Shinichi Otani, Takashi Yashiro, Yasunori Sohara and Shunsuke EndoShinichi Otani, Takashi Yashiro, Yasunori Sohara and Shunsuke Endo
  
  Objective: Reexpansion pulmonary edema (RPE) is a severe disorder, and its pathophysiology is not well understood. One proposed mechanism for RPE is that chemical substances such as cytokines increase alveolar permeability. Another possible mechanism is that alveolar distention during reexpansion causes physical damage. To test the hypothesis that sudden alveolar distention damages alveolar cellular structure and identify the underlying cause of RPE, we developed and evaluated the morphological characteristics of a rat RPE model. Methods: Lung from a rat model of RPE was observed by using live imaging from intravital fluorescence microscopy with fluorescein isothiocyanate labelled albumin as tracer, light microscopy, and electron microscopy (with and without horseradish peroxidase [HRP] as tracer). Results: Intravi.. Read More»
  DOI: 10.4172/2161-105X.1000396

  Abstract PDF