Transplantation Technologies & Research

Yasuo Takeuchi

Publications

• Research Article
  Dysfunction of Selective Suppression of Auto-Antibody Production in SLE Mouse and Reconstruction of this Mechanism by Induction of Bone-Marrow Chimerism
  Author(s): Emiko Takeuchi and Yasuo TakeuchiEmiko Takeuchi and Yasuo Takeuchi
  
  Background: Mixed chimerism induced by hematopoietic stem cell transplantation is useful in the treatment of autoimmune diseases, but the details of the mechanism by which mixed chimerism reverses the autoimmune state have not been determined. Here, we propose a potential mechanism in which newly developed T cells positively selected by the recipient’s thymus are able to regulate auto-reactive B cells. To test this hypothesis, we investigated whether major histocompatibility complex (MHC)/T cell receptor (TCR) cognate interaction was important for the regulation of auto-reactive B cells. We induced an auto-cross-reactive Antibody (Ab) by immunization using a foreign antigen with a homolog to an auto-antigen in a BXSB lupus mouse strain and achieved MHC-matched or mismatched mixed chimerism. Methods: Stable multi-lineage mixed chimeric .. Read More»
  DOI: 10.4172/2161-0991.S5-001

  Abstract PDF