Medicinal Chemistry

Yi Dai

Publications

• Research Article
  Pharmacokinetic Investigation of Main Bioactive Components from Epimedium-Derived Flavonoids in Rabbit Serum by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry
  Author(s): Liufang Hu, Yuanru Zheng, Yi Zhang, Zifei Qin, Yi Dai, Lin Qin, Zhihong Yao and Xinsheng YaoLiufang Hu, Yuanru Zheng, Yi Zhang, Zifei Qin, Yi Dai, Lin Qin, Zhihong Yao and Xinsheng Yao
  
  Background: Total Epimedium-derived flavonoids (EF) were reported to be a group of major bioactive constituents present in genus Epimedium for the treatment of osteonecrosis. The present study aimed to investigate the pharmacokinetics of main bioactive components of EF in rabbit. Methods: A rapid and sensitive method for the simultaneous determination of icariin, icariside I, icariside II and icaritin in serum was established and validated by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS). Serum samples were pretreated with water-saturated ethyl acetate. Furthermore, sample separation was achieved on an Waters BEH C18 column (50 mm × 2.1 mm, 1.7 μm) by gradient elution with acetonitrile-water (both including 0.1% formic acid) as mobile phase. Finally, pharmacok.. Read More»
  DOI: 10.4172/2161-0444.1000444

  Abstract PDF