Cancer Science & Therapy

Yongjun Jia

Publications

• Research Article
  The Role of Estrogen Receptors in Proliferation of Non-Small Cell Lung Cancer
  Author(s): Nan Yu, Yongjun Jia, Yong Yu, Lei Deng, Cong Shen, You-min Guo and Haifeng DuanNan Yu, Yongjun Jia, Yong Yu, Lei Deng, Cong Shen, You-min Guo and Haifeng Duan
  
  To explore the expression pattern of ERs in NSCLC tissues and assess their relationship with tumor histopathological variable. In our study, Ers expression was examined using Real-time PCR with specimens of 28 NSCLC patients. It was shown that both ERÉ? and Erβ were over expression in NSCLC tissues, and also the Mrna concentration of both ERÉ? and Erβ were significantly higher in primary tumor T2 stage than in T1 stage and higher in squamous carcinoma than in adenocarcinoma. However, the activation of ERÉ? and Erβ were completely different. To further explore the role of Ers in development and progression of NSCLC, we used Ers selective siRNA or antagonist in vitro experiments. The results showed that Erβ but not ERÉ? can mediate E2 induced cell growth, since siRNA targeting Erβ but not ERÉ? gene can induce cell cycle arrest at G1 phase by down regulation of c.. Read More»
  DOI: 10.4172/1948-5956.1000516

  Abstract PDF