Journal of Bioanalysis & Biomedicine

Yoshiaki Sugawara

Publications

• Review Article
  New Mode (Molecular-Sensing) of Heinz Body Formation Mechanisms Inherent in Human Erythrocytes: Basis for Understanding of Clinical Aspects of Drug-Induced Hemolytic Anemia and the Like
  Author(s): Yoshiaki Sugawara, Yuki Shigemasa, Yuko Hayashi, Yoko Abe, Ikumi Ohgushi and Eriko UenoYoshiaki Sugawara, Yuki Shigemasa, Yuko Hayashi, Yoko Abe, Ikumi Ohgushi and Eriko Ueno
  
  The human hemoglobin (Hb) molecule (α2β2) has two types of α–β interface (i.e., α1–β1[and α2–β2] and α1–β2[and α2–β1]). The latter α1–β2(and α2–β1) interface is associated with cooperative O2 binding, and exhibits principal roles if the molecule goes from its deoxygenated to oxygenated quaternary structure. The role of the former α1–β1(and α2–β2) interface has been unclear for a long time. In this regard, important and intriguing observations have been accumulating, so that a new gaze can be focused on the α1&nda.. Read More»
  DOI: 10.4172/1948-593X.1000078

  Abstract PDF