Journal of Bioanalysis & Biomedicine

Yosuke Aoki

Publications

• Research Article
  Application of Beta-lactam Therapeutic Drug Monitoring in Clinical Practice Using HPLC
  Author(s): Toshiharu Urakami, Yosuke Aoki, Mami Fukuoka, Hiroki Magarifuchi, Masaki Nagata, Zenzo Nagasawa, Yukitaka Nakano and Hiroshi FujitoToshiharu Urakami, Yosuke Aoki, Mami Fukuoka, Hiroki Magarifuchi, Masaki Nagata, Zenzo Nagasawa, Yukitaka Nakano and Hiroshi Fujito
  
  In beta-lactam therapy, investigation of the pharmacokinetic-pharmacodynamic (PK-PD) relationship has provided surrogate makers to predict clinical outcome. This study was designed to verify the therapeutic efficacy and clinical utility of beta-lactam therapeutic drug monitoring (TDM) in critically ill patients using high-performance liquid chromatography (HPLC). This cohort study included 13 patients who were intravenously administered ceftazidime (n = 6), cefepime (n = 1), imipenem (n = 1), meropenem (n = 1), or piperacillin (n = 4). Blood samples were collected at 3 time points fitted to a 1-compartment model, and concentrations were determined using HPLC. The PK-PD target was the percentage of the dosing interval during which the antibiotic concentration exceeded the minimum inhibitory concentration for the pathogens (%T > MIC), which is 50% for penicillins (piperacillin), 60% .. Read More»
  DOI: 10.4172/1948-593X.S3-001

  Abstract PDF