Journal of Computer Science & Systems Biology

Yosuke Kondo

Publications

• Research Article
  Dynamics of the Large Progenitor Toxin Complex of Clostridium botulinum
  Author(s): Yosuke Kondo and Satoru MiyazakiYosuke Kondo and Satoru Miyazaki
  
  Botulinum neurotoxins (BoNTs) are one of the potent toxins in nature but the toxicity is immediately eliminated by the harsh environment in the digestive tract because BoNTs are just a protein. However, BoNTs can get to synaptic junctions thanks to support of other proteins by aggregating with each other, combining with BoNTs and forming a large progenitor toxin complex (L-PTC). In order to explain how the complex formation enables the BoNTs to intrude into our body, we found that the three-dimensional structure of the L-PTC consists of an ovoid body with three legs and speculated important roles in the body and the legs. In the legs part, it is helpful for promoting absorption especially from the small intestine. Because experimental results showed that the legs are flexible and have specific binding sites of saccharides, the flexibilities may help the L-.. Read More»
  DOI: 10.4172/jcsb.1000214

  Abstract PDF