Journal of Cytology & Histology

Younossi ZM

Publications

• Research Article
  Non-Hematopoietic Circulating Progenitor Cells and Presence of Coronary Artery Disease in Patients with Non-Alcoholic Fatty Liver Disease
  Author(s): Elsheikh E, Jeffers T, Younoszai Z, Hunt S, Lam B, Otgonsuren M, Albano MC, Schneider I, Marsiglia B, Raybuck B and Younossi ZMElsheikh E, Jeffers T, Younoszai Z, Hunt S, Lam B, Otgonsuren M, Albano MC, Schneider I, Marsiglia B, Raybuck B and Younossi ZM
  
  Background: The levels and function of circulating progenitor cells (CPCs) may be affected by chronic metabolic diseases. Aim: To investigate the levels and functions of CPCs in patients with non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD). Methods: In this retrospective study, patients (n=82) undergoing elective coronary angiography for diagnosis of CAD were included. NAFLD was defined as presence of hepatic steatosis by ultrasound in the absence of other causes of liver disease and excessive alcohol use. After coronary angiography, patients were divided into NAFLD with CAD (n=24), NAFLD without CAD (n=13), only CAD (n=31) and Non-NAFLD and Non-CAD (n=14). CPCs were quantified by flow cytometry based on the expression of (CD34+, CD133+, CD34+CD133+) in presence or absence of the hematopoietic marker (CD45). We assessed serum levels of angiogenic growth fac.. Read More»
  DOI: 10.4172/2157-7099.1000423

  Abstract PDF