Pulmonary & Respiratory Medicine

Yuchun Gu

Publications

• Mini Review
  MicroRNAs and Smooth Muscle Cells Phenotypic Switching in PAH
  Author(s): Dongqing Guo, Lida Wu and Yuchun GuDongqing Guo, Lida Wu and Yuchun Gu
  
  Smooth muscle cells undergo a switching from contractile phenotype to synthetic phenotype in pulmonary hypertension characterized by excessive proliferation and migration of smooth muscle cells. MicroRNAs are small noncoding RNAs that can negatively regulate gene expression by directly binding with the 3’-UTR of mRNA. Numerous microRNAs have been reported to modulate the smooth muscle cells phenotypic switching and been urged to become possible therapeutic targets for pulmonary hypertension. This review will focus on the roles of microRNAs in regulating smooth muscle cellular phenotypic switching in PAH. .. Read More»
  DOI: 10.4172/2161-105X.1000168

  Abstract PDF