Journal of Hypertension: Open Access

Yunfu Lv

Publications

• Research Article
  Expression of M-CSF, TNF-β, IFN-γ, and IL-10 in Rats with Liver Cirrhosis and Hypersplenism and its Significance
  Author(s): Yunfu Lv, Jie Deng, Bookyong Yu, Qingqing Li and Xinqiu LiYunfu Lv, Jie Deng, Bookyong Yu, Qingqing Li and Xinqiu Li
  
  Objective: This study aimed to examine the expression of M-CSF, TNF-β, IFN-γ, and IL-10 in rats with liver cirrhosis and hypersplenism, and to investigate its significance. Methods: Seventy-two healthy male SD rats were randomly divided into a model group (n=60) and a control group (n=12). The rats in the model group were first gavaged with a 40% CCL4/peanut oil solution to develop cirrhosis and hypersplenism. The expression rates and intensities of the pro-inflammatory cytokines M-CSF, TNF-β, and IFN-γ, and the anti-inflammatory cytokine IL-10 in the spleen were measured and compared with the control group. The pro-inflammatory/anti-inflammatory cytokine ratio and its role were analyzed. Results: The positive expression rates of M-CSF, TNF-β, IFN-γ, and IL-10 in the model group (ci.. Read More»
  

  Abstract PDF