Journal of AIDS & Clinical Research

Yves Plumelle

Publications

• Research Article
  Eosinophils in HIV Patients Co-Infected by HTLV-1 and/or Strongyloïdes stercoralis: Protective or Harmful Depending on HIV Infection Stage
  Author(s): Yves Plumelle, Vanessa Cornely, Alice Eischen, Odile Bera, Nicole Desbois, Andre Cabie and Andre EdouardYves Plumelle, Vanessa Cornely, Alice Eischen, Odile Bera, Nicole Desbois, Andre Cabie and Andre Edouard
  
  Polymorphonuclear eosinophils are source of chemokines such as RANTES and IL-16. These chemokines suppress the in vitro viral replication of HIV primary strains and so could contribute to the resistance of infection in HIV seronegative patients despite their belonging to risk groups. Hypothesis considering eosinophilia as a protective factor against HIV infection by overexposing RANTES was tested. Therefore we studied the impact of co-infections of human T lymphotropic virus-1 (HTLV-1) and Strongyloïdes stercoralis (Ss), infectious agents potentially eosinophylogenic, on the eosinophilic reaction in HIV patients and on the patients' survival. From 1983 to 1996, 445 HIV infected patients had a follow-up for at least one year of whom 52% developed AIDS, 13% presented with HTLV-1, 15% with Ss coinfection and 23% showed eosinophilia superior to 1.. Read More»
  DOI: 10.4172/2155-6113.1000507

  Abstract PDF