Medicinal Chemistry

Zafar Iqbal Khan

Publications

• Research Article
  One Pot Synthesis of Some Novel Sulfonamide Derivatives Containing -NH2 Group: Spectral Characterization and Biological Evaluation
  Author(s): Hajira Rehman, Abdul Qadir M, Hazoor Ahmad Shad and Zafar Iqbal KhanHajira Rehman, Abdul Qadir M, Hazoor Ahmad Shad and Zafar Iqbal Khan
  
  A series of sulfonamide derivatives HR1-HR5 were synthesized in one step reaction (nucleophilic substitution reaction SN2). Structures of new products were confirmed by elemental and spectral analysis i.e., FTIR, UV, 1H NMR, 13C NMR, EIS-MS. In-vitro, antibacterial and anti-fungal activity of newly synthesized compounds was investigated against two bacterial strains: Escherichia coli and Staphylococcus aureus and two fungal strains: Aspergillum flavous and Aspergillum niger. It was found that among all tested compounds HR2 showed good antibacterial activity with MIC 1.13 × 10-3 and 1.54 × 10-3 for S. aureus and E. coli respectively. While HR4 showed good antifungal activity with inhibition zone 25.2 ± 0.12 mm (MIC: 71.2 × 10-3 mol/L) and 17.1 ± 55.5 mm (MIC: 98.9 × 10-3 mol/L) against A. flavous.. Read More»
  DOI: 10.4172/2161-0444.1000465

  Abstract PDF