Faculty of Medicine,
Zagazig, Egypt, Faculty of Medicine, Tibah University, Madinah
Saudi Arabia
Research Article
Effect of Triclosan on the Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Ellagic Acid: Histological and Biochemical Study
Author(s): Zeinab A. Hassan, Manal R. Abd El-Haleem and Ghada N. MansourZeinab A. Hassan, Manal R. Abd El-Haleem and Ghada N. Mansour
Background: Triclosan (TCS) is widely used broad spectrum bactericide. Ellagic acid (EA) has radical scavenging properties.
Aim of the work: to assess the structure of the renal cortex after TCS administration and to determine the possible protective role of EA.
Materials and Methods: Thirty adult male albino rats were divided into three groups; control group, TCS treated group: TCS was administered 200 mg/kg, once daily for six week, by oral gavages. TCS-EA treated group: received in the same doses of TCS and EA (30 mg/kg) for six weeks. Blood urea nitrogen (BUN), serum creatinine (Sc) and uric acids (UA) were measured. Renal cortex samples were processed for light and electron microscope examination.
Results: Examination of TCS treated group revealed increased glomerular cellularity in some c.. Read More»
DOI:
10.4172/2157-7099.1000285
Journal of Cytology & Histology received 2476 citations as per Google Scholar report