Journal of Tissue Science and Engineering

Zeinab Najafi-Gharavi

Publications

• Research Article
  pH-Sensitive Chitosan Hydrogel with Instant Gelation for Myocardial Regeneration
  Author(s): Alimirzaei F, Vasheghani-Farahani E, Ghiaseddin A, Soleimani M, Pouri and Zeinab Najafi-GharaviAlimirzaei F, Vasheghani-Farahani E, Ghiaseddin A, Soleimani M, Pouri and Zeinab Najafi-Gharavi
  
  Recently in situ injectable hydrogels have received considerable attention to regenerate failure heart tissue after myocardial infarction (MI). But two criteria remain crucial: first, defining their chemical composition and structural parameters because they must be fabricated to withstand physiological condition while having high cell retention; second, providing the hydrogel with short gelation time to protect the cells from washout and extrusion in the injection site. In this study, two different pH-sensitive hydrogels with instant gelation in the presence of aqueous acetic acid (WH sample), and DMEM medium along with acetic acid (MH sample) were prepared. The morphology and structural and mechanical properties of the hydrogels were evaluated by SEM, FTIR and compressive strength test, respectively. Also, the equilibrium swelling ratio of each hydrogel and their degradation rate as.. Read More»
  DOI: 10.4172/2157-7552.1000212

  Abstract PDF