Metabolomics:Open Access

Zhang L

Publications

• Research Article
  Evaluating the Association of Heme and Heme Metabolites with Lung Cancer Bioenergetics and Progression
  Author(s): Hooda J, Alam MM and Zhang LHooda J, Alam MM and Zhang L
  
  Emerging experimental data increasingly show that despite the enhanced glycolytic flux, many types of cancer cells exhibit intensified oxygen consumption or mitochondrial respiration. Even under hypoxia, cancer cells can maintain oxidative phosphorylation at a substantial rate. Heme is a central factor in oxygen utilization and oxidative phosphorylation. It serves as a prosthetic group in many proteins and enzymes involved in mitochondrial respiration. Notably, our recent work showed that non-small-cell lung cancer (NSCLC) cells and xenograft tumors exhibit substantially increased levels of an array of proteins promoting heme synthesis, uptake and function. These proteins include the rate-limiting heme biosynthetic enzyme ALAS, transporter proteins, and various types of oxygen-utilizing hemoproteins such as cytoglobin and cytochromes. In contrast, lowering.. Read More»
  DOI: 10.4172/2153-0769.1000150

  Abstract PDF