Molecular Biology: Open Access

Zhiguo Zheng

Publications

• Research Article
  Over-Expressions of Serum miR-182-5p, miR-363-3p, and miR-378a-3p serve as Biomarkers in Hepatocellular Carcinoma
  Author(s): Siquan Zhang, Liming Zhu, Huafeng Liu, Shourong Liu, Nianbo Zhao, Jing Wu, Xiaoxiao Huang, Yujuan Zhang, Jie Jin, Dajing Wang, Zhiguo Zheng and Xianfeng DingSiquan Zhang, Liming Zhu, Huafeng Liu, Shourong Liu, Nianbo Zhao, Jing Wu, Xiaoxiao Huang, Yujuan Zhang, Jie Jin, Dajing Wang, Zhiguo Zheng and Xianfeng Ding
  
  Serum α-fetoprotein (AFP) has been used as an early diagnostic biomarker of hepatocellular carcinoma (HCC), however the sensitivity and specificity of detection are poor. Therefore, new markers remain to be explored. MicroRNAs (miRNAs) are a class of small RNAs which could contribute to tumorigenesis by interaction with targeted mRNAs. MiRNAs are abundant in the circulating blood and are potentially useful for early diagnosis of hepatocellular carcinoma. In this study, we screened a group of candidate miRNAs (miR-182-5p, miR-363-3p, and miR-378a-3p) in serum, which were found to be up-regulated in HCC patients compared with in the healthy controls. Analysis of the receiver operating characteristic (ROC) curve suggested that these three serum miRNAs had merits in the diagnosis of HCC (AUC=0.802, 0.845, 0.880, respectively). Furthermore, these candidate miRNAs can also differentiat.. Read More»
  DOI: 10.4172/2168-9547.1000154

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